Papers, studies and theses

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

Abstract Virgin olive oil (VOO) constitutes the main source of fat in the Mediterranean diet. VOO is rich in oleic acid, displaying health-promoting properties, but also contains minor bioactive components, especially phenolic compounds. Hydroxytyrosol (HT), the main polyphenol of olive oil, has been reported to be the most bioactive component. This review aims to compile […]

body weight|dyslipidemia|hydroxytyrosol|hyperglycemia|hypertension|inflammation|Oleuropein|olive oil|oxidative stress|tyrosol

March 12, 2023

Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements

Abstract Hydroxytyrosol (HT) is an amphipathic functional phenol found in the olive tree, both in its leaves and fruits, in free or bound forms, as well as in olive oil and by-products of olive oil manufacture. The European Food Safety Authority recommends regular consumption of HT due to its several beneficial effects on human health, […]

March 12, 2023

Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Skin aging is a complex biological process influenced by a combination of endogenous or intrinsic and exogenous or extrinsic factors due to environmental damage. The primary environmental factor that causes human skin aging is the ultraviolet irradiation from the sun. Recently, it was established that the long-term exposure to light-emitting-diode-generated blue light (LED-BL) from electronic […]

antioxidants, blue light, cell culture, oxidative stress, photoaging, skin

March 26, 2026

Safety and efficacy of hydroxytyrosol-based formulation on skin inflammation: in vitro evaluation on reconstructed human epidermis model

Background: Atopic dermatitis is a multifactorial immune-mediated skin disorder characterized by an alteration of epidermal barrier function and onset of skin lesions, which range from mild erythema to severe lichenification. Treatment consists in hydration with possible use of topical or immunomodulatory corticosteroids, which, however sometimes showed side effects. Recently, the interest in natural compounds has grown […]

Anti-inflammatory effect, Atopic dermatitis, Histology and immunohistochemistry, hydroxytyrosol, In vitro reconstructed human epidermis, Semi-solid formulation

March 26, 2026

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

Fibroblasts contribute to maintaining tissue integrity and homeostasis and are a key cell population in wound healing. This cell population can be stimulated by some bioactive compounds such as extra virgin olive oil (EVOO) polyphenols. The aim of this study was to determine the effects of hydroxytyrosol (htyr), tyrosol (tyr), and oleocanthal (ole) phenolic compounds […]

extra- virgin olive oil, fibroblasts, phenolic compounds, tissue regeneration, wound healing

March 26, 2026

Effects of a Phenol-Enriched Purified Extract from Olive MillWastewater on Skin Cells

Olive trees (Olea europaea) and their processed products, such as olive oil, play a major role in the Mediterranean way of life. Their positive impact on human health is being intensely investigated. One research topic is the identification of new application areas of olive mill wastewater (OMWW). OMWW is characterized by the high content of […]

antimicrobial effects, HaCaT cells, IL-8, NHEK cells, ROS-assay, tumor invasion skin model

March 30, 2026

Exploring Olive Pomace for Skincare Applications: A Review

The cosmetic industry is continuously searching for new active ingredients in an effort to attend to consumer demands which, in recent years, are focused on more natural and environmentally friendly products, obtained from sustainable resources. Nevertheless, they are required to provide cosmetologically appealing skincare products, ultimately with the purpose of improving skin appearance. The olive […]

cosmetics, formulation’s design, hydroxytyrosol, olive oil by-products, sustainability

March 30, 2026