Papers, studies and theses
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Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells
Several studies relate Mediterranean diet and virgin olive oil (VOO) intake with lower risk of several chronic diseases, including breast cancer. Many of them described antitumor properties of isolated minor compounds present in VOO, but beneficial properties of VOO arise from the effects of all its compounds acting together. The aim of the present study […]
Tags: antitumor, apoptosis, breast cancer, comet assay, DNA damage, proliferation, virgin olive oils
March 12, 2023
Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial
Mild cognitive impairment (MCI) and early Alzheimer’s disease (AD) are characterized by blood–brain barrier (BBB) breakdown leading to abnormal BBB permeability ahead of brain atrophy ordementia. PreviousfindingsinADmousemodelshavereportedthebeneficialeffectofextra-virgin oliveoil(EVOO)againstAD,whichimprovedBBBandmemoryfunctionsandreducedbrainamyloidβ (Aβ) and related pathology. This work aimed to translate these preclinical findings to humans in individuals with MCI. We examined the effect of daily consumption of refined […]
Tags: Alzheimer’s disease, amyloid beta peptides, blood–brain barrier, cognitive function, contrast-enhanced MRI, extra- virgin olive oil, functional MRI, mild cognitive impairment, refined olive oil, tau
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