Papers, studies and theses
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Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial
Mild cognitive impairment (MCI) and early Alzheimer’s disease (AD) are characterized by blood–brain barrier (BBB) breakdown leading to abnormal BBB permeability ahead of brain atrophy ordementia. PreviousfindingsinADmousemodelshavereportedthebeneficialeffectofextra-virgin oliveoil(EVOO)againstAD,whichimprovedBBBandmemoryfunctionsandreducedbrainamyloidβ (Aβ) and related pathology. This work aimed to translate these preclinical findings to humans in individuals with MCI. We examined the effect of daily consumption of refined […]
Tags: Alzheimer’s disease, amyloid beta peptides, blood–brain barrier, cognitive function, contrast-enhanced MRI, extra- virgin olive oil, functional MRI, mild cognitive impairment, refined olive oil, tau
March 12, 2023
Synergistic Effect of Squalene and Hydroxytyrosol on Highly Invasive MDA-MB-231 Breast Cancer Cells
Several studies relate Mediterranean diet and virgin olive oil (VOO) intake with lower risk of several chronic diseases, including breast cancer. Many of them described antitumor properties of isolated minor compounds present in VOO, but beneficial properties of VOO arise from the effects of all its compounds acting together. The aim of the present study […]
Tags: antitumor, apoptosis, breast cancer, comet assay, DNA damage, proliferation, virgin olive oils
Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD
Background: The rise in paediatric non-alcoholic fatty liver disease (NAFLD) is particularly alarming. We recently reported that Hydroxytyrosol (HXT) and Vitamin E (VitE) may improve oxidative stress, insulin resistance, and steatosis in children with biopsy-proven NAFLD. Aim: Here, we investigated if HXT+VitE may reduce systemic inflammation in the above-mentioned patients.Methods: This study analysed the plasma […]
Tags: Cytokines, hydroxytyrosol, NAFLD, Paediatric NAFLD, Vitamin E
Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model
Purpose: Recent epidemiological studies have shown that habitual consumption of extra virgin olive oil (EVOO), the characteristic culinary fat of the Mediterranean area, is effective in the prevention of diverse types of digestive disorders such as inflammatory bowel disease. Many of these benefits are, in addition to its high proportion of oleic acid, due to […]
Tags: Chronic colitis, COX-2, Cytokines, extra- virgin olive oil, hydroxytyrosol, iNOS
Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the […]
Tags: anticancer perspectives, hydroxytyrosol, metabolism, Oleuropein, olive oil phenols
Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial
Purpose: Dietary polyphenols have been demonstrated to favourably modify a number of cardiovascular risk markers such as blood pressure (BP), endothelial function and plasma lipids. We conducted a randomised, double-blind, controlled, crossover trial to investigate the effects of a phenolic-rich olive leaf extract (OLE) on BP and a number of associated vascular and metabolic measures.Methods: A […]
Tags: Blood pressure, Cardiovascular disease, Oleuropein, Olive leaf, Plasma lipids, Polyphenols
Anti-inflammatory and anti-aging effects of hydroxytyrosol on human dermal fibroblasts (HDFs)
Background: Hydroxytyrosol is discovered in a form of elenolic acid ester oleuropein in olive leaf and oil. The anticarcinogenic, antioxidant, and anti-inflammatory effects of hydroxytyrosol have been reported in the food, medical, pharmaceutical, and life science fields. But it has not been studied on skin biology field. This study is demonstrated using UVA-induced cellular aging […]
Tags: Hydroxytyrosol, Fibroblasts, Anti-inflammatory, Cellular senescence, Anti-aging, Ultraviolet A
Post-prandial effects of high-polyphenolic extra virgin olive oil on endothelial function in adults at risk for type 2 diabetes: A randomized controlled crossover trial
Background: Effects of olive oil on cardiovascular risk have been controversial. We compared the effects of high-polyphenolic extra virgin olive oil (EVOO) and refined olive oil without polyphenols on endothelial function (EF) in adults at risk for Type 2 diabetes mellitus (T2DM).Methods: Randomized, controlled, double-blind, crossover trial of 20 adults (mean age 56.1 years; 10 women, […]
Tags: Olive oil, Olea europea, polyphenols, oleuropein, hydroxytyrosol, anticancer therapy
Twelve-month consumption of a polyphenol extract from olive (Olea europaea) in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with osteopenia
Objectives: Osteoporosis is a skeletal disorder characterized by impaired bone turnover and compromised bone strength, thereby predisposing to increased risk of fracture. Preclinical research has shown that compounds produced by the olive tree (Olea europaea), may protect from bone loss, by increasing osteoblast activity at the expense of adipocyte formation. The aim of this exploratory […]
Tags: Oleuropein, osteocalcin, bone mineral density, lipid profile.
An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis
Objectives: To investigate a 6-month intervention with an olive leaf extract (OLE) on knee functionality and biomarkers of bone/cartilage metabolism and inflammation. Design: This randomized, double-blind, placebo-controlled, multi-centric trial included 124 subjects with knee pain or mobility issues. Subjects received twice a day one capsule of placebo or 125 mg OLE (Bonolive™, an OLE containing […]
Tags: function, joint pain, nutritional supplement, oleuropein